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富血小板纤维蛋白预防下颌角肥大截骨缩小术后出血及肿胀的临床效果

Clinical effects of platelet rich fibrin in prevention of bleeding and swelling after mandibular angle reduction

摘要目的 观察富血小板纤维蛋白(platelet-rich fibrin,PRF)预防下颌角肥大截骨缩小术后出血和面部创伤性肿胀的临床效果.方法 对行下颌角肥大截骨缩小术26例纳入研究.采用半侧颜面自身对比研究,随机将面部左右侧分为贫血小板血浆(platelet-poor plasma,PPP)组和PRF组,其中PRF组术中制备自体PRF置于下颌截骨创面,PPP组则放置PPP.术后对PRF组和PPP组出血引流量和面部肿胀程度进行测量.结果 术后PRF组引流量为(20.35±7.40) ml,PPP组为(43.23±11.96) ml,两组比较差异有统计学意义(P<0.05).术后第3天,均有肿胀病例,面部肿胀评分PRF组为(1.19±0.40)分,PPP组为(2.62±0.64)分,差异有统计学意义(P<0.05).结论 使用PRF覆盖创面可以减少术后出血和缓解面部肿胀.

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abstractsObjective To observe the clinical effect of platelet-rich fibrin (PRF) on prevention of postoperative hemorrhage and facial traumatic swelling in patients with mandibular angle osteotomy.Methods Twenty-five patients with mandibular angle hypertrophy were included in this study from January 2014 to November 2015.Split face comparative study was carried out to use the left and right sides as the experimental side and the control side,respectively.The PRF in the experimental side was placed in the mandibular osteotomy,while the control side was placed in platelet-poor plasma (PPP).After operation,the drainage volume and facial swelling degree were measured.Results The drainage volume of the experimental group (PRF group) was (20.35 ±7.40) ml,the control group (PPP group) was (43.23±11.96) ml,and the difference was statistically significant (P<0.05).There was no such case without swelling in postoperative third day.The facial swelling score on the experimental side was (1.19±0.40),the control side was (2.62±0.64),and two groups of postoperative facial swelling scores were significantly different (P<0.05).Conclusions The PRF can reduce postoperative bleeding and facial swelling after mandibular angle osteotomy.

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作者 王昕 [1] 陈小平 [1] 林金德 [2] 郑翔宇 [2] 顾娜 [2] 尹康 [2] 胡晓庆 [2] 刘大猛 [2] 万昌阳 [2] 学术成果认领
作者单位 浙江医院整形科,杭州,310013 [1] 南京医科大学附属友谊整形外科医院整形美容科 210029 [2]
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DOI 10.3760/cma.j.issn.1671-0290.2019.02.013
发布时间 2019-11-19
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