摘要目的 探讨先天性腭裂胎羊宫内发育及母羊子宫血流动力学的B超影像学特点.方法 取40只8～12月龄杂交波尔雌性山羊,体重35～55 kg,以配种日期定为孕0 d,于孕30 d经B超确认怀孕后将动物分为实验组和正常对照组,每组20只.实验组分别于孕31～42 d肌内注射毒藜碱15 mg/d诱导胎羊形成先天性腭裂动物模型,正常对照组不作处理,待其正常孕育.于孕60 d经B超检测两组子宫动脉及宫内影像学观察.结果 药物导致母羊流产3只,实验组最终纳入17只,正常对照组20只妊娠山羊达到孕60 d完成检查.孕60 d,实验组与正常对照组母羊单侧子宫动脉平均流速和血流量差异有统计学意义(P<0.05).而其他数据差异无统计学意义(P>0.05).结论 由毒藜碱致畸的孕腭裂胎羊 、孕60 d母羊宫内血流量与平均流速略高于正常孕羊,可能跟毒藜碱的其他毒性作用有关.

abstractsObjective To study the dynamic blood character .of pregnant goat's uterus based on pregnant hybrid boer goats and B-ultrasound tompography .Methods Fourty boer hybrid goats were involved in our experiment ,aged from 8 m to 12 m ,and weighted from 35 kg to 55 kg .Mating day was defined as 0 d ;at 30 d goats was assured pregnant by B type ultrasonic test ,and they were sepa-rated into two groups .Test group had anabasine muscle injected from 31 d to 42 d with 15 mg/d to form cleft palate ;control group (20 goats) had no treatment .At pregnant 60 d ,all pregnant goats were examined by B type ultrasonic test .Results Three goats of test group had aborted ;test group had 17 goats and control group had 20 goats .At pregnant 60 day ,there was the significant difference (P < 0 .05) in mean velocity and total blood amount ,but no statistical difference (P > 0 .05) in other index between the two groups .Conclusions The uterine blood amount and mean velocity are increased in prognant goats with cleft palate fetus compared with normal pregnant goat ,suggesting anabasine may have other functions including teratogenicity .