摘要目的 评估755 nm皮秒点阵激光治疗面部皮肤光老化的疗效和安全性.方法 2016年1月至2018年7月,中国医学科学院皮肤病医院激光科收集26例面部皮肤光老化患者,皮秒点阵激光治疗3次,每次治疗间隔4周.治疗参数:FocusTM微透镜阵列技术,光斑6 mm,能量密度0.71 J/cm2,频率5 Hz.由未参与研究的2位皮肤科专家根据治疗前后照片进行疗效评估.末次治疗后1个月 、3个月随访时,患者对皱纹 、皮肤紧致度 、肤色三方面疗效进行自我评估及满意度评估.每次治疗及随访时,详细记录所有不良反应.结果 26例患者全部完成3次治疗及随访.末次治疗后1个月 、3个月时,光老化评分分别为(1.27±0.53)分 、(1.58±0.70)分,与治疗前评分(2.62±0.80)分相比,差异有统计学意义(P<0.05).末次治疗后1个月,92％ 患者诉皱纹有改善,96％ 患者诉皮肤紧致,89％ 患者诉肤色有改善;末次治疗后3个月,皱纹 、皮肤紧致度 、肤色改善患者分别为92％ 、96％ 、85％.末次治疗后1个月 、3个月,对治疗结果感到满意和非常满意患者分别为92.3％ 、88.5％.治疗中6例患者有严重疼痛,20例中度疼痛,均能耐受.26例患者治疗过程中均有轻微红肿,24 h内自行消退.无患者出现瘢痕或色素异常.结论 755 nm皮秒点阵激光治疗面部皮肤光老化安全 、高效,停止治疗后3个月时疗效仍能维持.

abstractsObjective To evaluate the efficacy and safety of a 755 nm picosecond Alexandrite la-ser with a diffractive lens array in the treatment of facial photoaged skin .Methods Twenty-six pa-tients with facial photoaging were recruited and received 3 treatments at 4-week intervals .Laser energy was applied over the entire face at a fixed spot size of 6 mm ,with a fluence of 0 .71 J/cm2 and 5Hz . Blinded clinical assessment was performed by 2 independent dermatologists on a 5-point global pho-toaging scale (GPS) .Patients were also questioned on the extent of improvement of rhytides ,skin tightening ,and complexion with a 4-point global aesthetic improvement scale (GAIS) and satisfaction . Adverse events were also evaluated .Results Twenty-six patients completed the treatment .Compared with the baseline ,there was a significant improvement in facial photoaged skin after 3 treatments ,and these positive outcomes were maintained up to the 3-month follow-up ,according to the GPS and GAIS scores .Moderate pain and transient erythema were observed as the two main discomforts associated with the treatment .Most patients were satisfied with the treatment .Conclusions This 755 nm pico-second Alexandrite laser with a diffractive lens array optic is effective in the treatment offacial pho -toaged skin ,and the therapy also seems safe and well tolerated .