摘要目的 观察A型肉毒毒素微滴注射联合强脉冲光技术改善面部年轻化的疗效.方法2018年1月至2018年9月,武汉大学人民医院医疗美容科门诊面部光老化患者30例,男1例,女29例.年龄35～55岁,平均45.56岁.分为联合治疗组和强脉冲光组各15例,30例患者均行3次全面部强脉冲光治疗,每次治疗间隔1个月;其中联合治疗组于第1次强脉冲光治疗后30 min,行颊部A型肉毒毒素微滴注射.两组患者在治疗前 、治疗后1个月 、3个月进行VISIA CR图像分析,并分析两组治疗前后色斑 、皱纹 、纹理 、毛孔 、红斑及有效率评价,同时进行患者满意度调查.结果治疗后1个月联合治疗组有效率高于强脉冲光组(χ2=6.208,P=0.045),但治疗后3个月两组疗效差异不明显(χ2=1.077,P=0.584).满意度两组差异无统计学意义(P>0.05).30例患者能耐受强脉冲光A型肉毒毒素微滴注射时的红斑 、瘀斑等不良反应,且均在对症处理后消失.结论A型肉毒毒素微滴注射联合强脉冲光行面部年轻化治疗,短期内能增加疗效,是一种疗效可靠 、安全的面部抗衰老治疗方案.

abstractsObjective To investigate the efficacy of micro botulinum toxin A (BTX) combined with intense pulsed light (IPL ) treatment in facial rejuvenation patients .Methods A total of thirty patients (1 male ,29 females ,aged 35 to 55 years with average age of 45 .56 years) with facial pho-toaging in the Department of Medical Cosmetology ,Renmin Hospital of Wuhan University from Jan . to Sept .2018 were enrolled as out-patients .Thirty patients were recruited in the study and randomly assigned averagely to the combination group and control group .All received standard IPL treatment every month for a total of 3 sessions .Patients in combined group received microinjections of diluted BTX on cheeks after the first IPL .VISIA CR images were analyzed before ,1 month and 3 months af-ter treatment .Dermatologists assessed the improvement of color spots ,wrinkles ,texture ,pore ,and erythema improvement .The patient satisfaction survey was analyzed .Results The effective rate of the combined group was better than that of the intense pulsed light group one month after treatment (χ2 = 6 .208 ,P = 0 .045) ,but there was no significant difference between the two groups three months after treatmen (χ2 = 1 .077 ,P = 0 .584t) .The patient satisfaction survey showed that there was no sta-tistical difference between the two groups .Slight erythema and bruising were observed but disappeared at the end of the treatment (P > 0 .05) .Conclusions The adjunctive use of MicroBTX can enhance treatment efficacy of IPL alone .It is a highly effective and safe treatment method for facial antiaging .