摘要目的 探讨不同剂量A型肉毒毒素治疗腋臭患者的临床效果.方法 2016年2月至2018年2月,南京大学医学院附属鼓楼医院整形烧伤科根据腋臭病情分级选取200例腋臭患者,其中轻中度100例,重度100例,分别分为100 U组和200 U组两个亚组,各50例.两组患者双侧腋窝分别注射A型肉毒毒素100 U和200 U,比较两组术后有效率和复发率.结果 在随访期内,轻中度腋臭患者两组有效率及复发率差异无统计学意义(均P＞0.05).重度腋臭患者,治疗3个月后100 U组有效率64.0％,200 U组有效率82.0％,差异有统计学意义(x 2=4.110,P＜0.05).经过6个月随访,100 U组复发率46.0％,200 U组复发率22.0％,差异有统计学意义(x2=6.417,P＜0.05).结论 基于腋臭的严重程度分级选择合适剂量A型肉毒毒素,可达到个体化的精准治疗,提高患者满意度.

abstractsObjective To explore the therapeutic effect of different doses of botulinum toxin A injections on bromhidrosis.Methods A total of 200 cases were divided into mild-to-moderate group (N=100) and severe group (N=100) based on the grade of bromhidrosis,and each group was further divided into two groups:low dose group (50 cases) were treated by botulinum toxin A injections (100 U) and high dose group (50 cases) were treated with 200 U for bilateral axillary.The total effective rate and recurrence rate in both groups were compared.Results In the mild to moderate group,after treatment for 3 months,the total effective rate of both groups had no statistical difference (P＞ 0.05),and the same with recurrence rate in 6 months follow-up (P＞0.05).In the severe group,after treatment for 3 months,the total effective rate of the high dose group (82％) was significantly higher than that of the low dose group (64％),with statistical significance (x2 =4.110,P＜0.05).After 6 months follow-up,recurrence rate in the high dose group (22％) was significantly lower than that of the low dose group (46％),with statistical significance (x2 =6.417,P ＜ 0.05).Conclusions A suitable dose of botulinum toxin A can be selected based on the severity of bromhidrosis,which is a individualized therapy for cost savings and might have potential benefits for patients with osmidrosis.