摘要目的:探讨水光注射联合医用保湿修复霜治疗玫瑰痤疮的疗效和安全性。方法:2018年1—12月，陆军军医大学第一附属医院皮肤科将100例玫瑰痤疮患者分为联合组、水光组、保湿组。联合组及水光组给予水光注射，每月1次，共治疗3个月；联合组及保湿组使用外用医用保湿修复霜每日早晚，各1次，共治疗3个月。治疗师根据皮损评分标准进行评估，对不良反应进行记录。结果:治疗12周后，联合组、水光组、保湿组治疗前后积分差值分别为10.01±1.23、9.18±0.92、4.63±1.01，3个组患者治疗后红斑、丘疹脓疱、瘙痒等症状积分都有好转，联合组效果明显优于水光组( t＝0.678， P<0.05)和保湿组( t＝1.195， P<0.05)，差异有统计学意义。3个组有效率分别为94.38%、89.91%、48.12%；均未见严重不良反应。 结论:水光注射联合医用保湿修复霜治疗玫瑰痤疮安全、有效。

abstractsObjective:To evaluate the efficacy and safety of water injection therapy combined with medical moisturizing repair cream in the treatment of rosacea.Methods:Total of 100 patients with types I and II rosacea in the Department of Dermatology, the First Affiliated Hospital of Army Medical University were randomly divided into three groups: comprehensive group (treatment group), hydrate group (control group 1) and moisturizing group (control group 2). Comprehensive group and water light group were given water injection therapy, once a month, a total of 3 times of treatment; in the comprehensive group and the moisturizing group, topical medical moisturizing repair cream was used once in the morning and in the evening, for a total of 12 weeks. After unified training, the therapists evaluated the skin lesions according to the scoring criteria and recorded the adverse reactions, for a total of 12 weeks.Results:After 12 weeks of treatment, the integral difference values before and after treatment were 8.01± 2.43, 7.68±2.16 and 5.63 ±2.19 respectively in the comprehensive group, the water injection therapy group and the moisturizing group, with statistically significant differences ( P<0.05). The effective rates of the three groups were 94.38%, 89.91% and 48.12%. No serious adverse reactions were observed. Conclusions:The water injection therapy combined with medical moisturizing and repairing cream is safe and effective in the treatment of rosacea; it is more effective than the moisturizing and repairing cream.The water injection therapy combined with medical moisturizing and repairing cream has advantages but is not obvious enough.