摘要目的:探讨含寡肽及生物多糖护肤品对敏感性皮肤屏障功能改善的效果及安全性。方法:2019年12月至2020年7月，于北京同仁医院皮肤科门诊诊治的敏感性皮肤志愿者30例，男3例、女27例，年龄18~57岁，平均34岁，病程1~10年，平均5.75年。入组当天用含寡肽及生物多糖产品导入治疗1次。在治疗前、治疗7 d及28 d后进行VISIA皮肤图像分析仪分析、皮肤生理指标测定、受试者自我症状体征改善评估，研究者评估，并通过问卷调查方式评估产品安全性。结果:VISIA数据显示，治疗后VISIA红色区绝对值较治疗前有明显降低，其中治疗28 d后与治疗前相比，红色区有明显改善( P<0.05)。皮肤生理测试显示，治疗后含水量与治疗前对比，差异均有统计学意义(均 P<0.05)。受试者经皮失水量值与基线对比有明显改善( P<0.05)。研究过程中，未发生与产品相关的不良反应。 结论:含寡肽及生物多糖护肤品可提高敏感性皮肤角质层含水量，降低经皮失水量，对皮肤屏障功能有一定改善作用，安全性较高。

abstractsObjective:To evaluate the effects and adverse reactions of external skin care products containing oltides and bio-polysaccharides on epidermaligopep barrier function of sensitive skin.Methods:From December 2019 to July 2020, there were 30 sensitive skin volunteers diagnosed and treated in the dermatology clinic of Beijing Tongren Hospital, including 3 males and 27 females, aged 18-57 years, with an average of 34 years, and the course of disease was 1-10 years, with an average of 5.75 years. They were treated once with products containing oligopeptides and biopolysaccharides on the day of enrollment. Before treatment, 1 week and 4 weeks after treatment, we observed and evaluated through VISIA analysis; skin physiological index measurement, subjective and objective improvement assessment, and product safety were evaluated through questionnaire surveys.Results:The VISIA data showed that the red zone was significantly lower than the baseline, and the data at the 4th week and before treatment were significantly improved ( P<0.05). On skin physiology, the test showed that after treatment, the difference between two follow-up visits and the water content before was statistically significant ( P<0.05). TEWL value after 4 weeks of treatment was significantly improved as compared with the baseline ( P<0.05). During the entire study process, no adverse reactions related to the product occurred. Conclusions:This skin care product containing oligopeptides and biopolysaccharides can increase the water content of the sensitive skin, reduce the water loss through the skin, and improve the skin barrier function. Meanwhile, no server adverse reaction is detected through the whole experiment.