摘要近年来大量研究证实泛素样含植物同源结构域和环指结构域1 (ubiquitin-like with PHD and RING finger domains 1,UHRF1)是一种与肿瘤发生相关的核蛋白基因,在表观遗传修饰过程中具有重要的调控作用,尤其是在DNA甲基化与组蛋白甲基化的调控方面.UHRF1由于其特有的结构域,在细胞生物学功能调控中起到非常重要的作用,如细胞增殖、周期和凋亡等.另外,在多种肿瘤组织和细胞中异常高表达的UHRF1可能与肿瘤血管新生密切相关.本文主要综述UHRF1对DNA甲基化及组蛋白甲基化的调控作用,并探讨了UHRF1在血管新生过程中可能发挥的表观遗传学调控作用.

abstractsMany recent studies have proved that ubiquitin-like with PHD and RING finger domains 1 (UHRF1) is an important nuclear protein associated with tumorigenesis,which plays a significant role in epigenetic regulation,especially in DNA methylation and histone methylation.For its particular domains,UHRF1 plays a critical role in biological behaviors including cell proliferation,cell cycle,and apoptosis.Overexpression of UHRF1 in various tumors is closely associated with the angiogenesis in tumors.This paper will provide a review of the regulation of UHRF1 in DNA methylation and histone methylation,and discuss the potential epigenetic role of UHRF1 in angiogenesis.