摘要目的:分析上海市某区药品监管平台对重点监控药品实施处方点评的效果及点评处方不合格率的影响因素。方法:某区药品监管平台自2018年6月开始实施处方点评，提取其6—12月所有重点监控药品的点评处方及关联信息。以6月的处方不合格率作为基线数据，采用 χ2检验和logistics回归模型进行数据分析。 结果:2018年6—12月，临床药师共对19 084张门急诊处方和10 607张住院处方进行点评。门急诊和住院处方不合格率分别从6月的16.52%和23.28%下降为12月的4.45%和13.80%。logistics回归分析显示门急诊处方的点评不合格率低于住院处方，医院点评处方不合格率低于社区卫生服务中心的；辅助用药和营养药物的处方不合格率低于抗菌药物的。结论:对重点监控药品的处方点评能够有效促进合理用药，今后应加强对社区卫生服务中心的技术支持和对临床医生、药师的专业培训。

abstractsObjective:To analyze the effects of prescription reviews of key monitored drugs using the drug regulatory platform in a district of Shanghai, and the influencing factors for the rate of unqualified prescriptions.Methods:A drug regulatory platform in a district in Shanghai began to implement prescription reviews since June 2018, extracting the reviewed prescriptions of all key monitored drugs and related information from June to December. Taking the unqualified rate of prescription in June as the baseline data, the χ2 test and the logistics regression model were used for data analysis. Results:From June to December 2018, clinical pharmacists reviewed 19 084 outpatient and emergency prescriptions and 10 607 inpatient prescriptions. The unqualified rates of outpatient and emergency prescriptions and inpatient prescriptions dropped from 16.52% and 23.28% in June to 4.45% and 13.80% in December, respectively. Logistics regression analysis showed that the rate of unqualified reviews of outpatient and emergency prescriptions was lower than that of inpatient prescriptions, and the rate of unqualified prescriptions in hospital was significantly lower than that in community health service centers; the rate of unqualified prescriptions for auxiliary drugs and nutritional drugs was significantly lower than that of antibacterial drugs.Conclusions:The prescription reviews of key monitored drugs can effectively promote the rational use of drugs. In the future, it is recommended to strengthen technical support for community health service centers and professional training for clinicians and pharmacists.