摘要目的 分析上海市杨浦区肺癌患者的发病和死亡情况.方法 整理上海市肿瘤病例登记和管理系统中的杨浦区户籍人群肺癌病例资料,应用年平均变化百分比(APC)模型分析肺癌患者发病的时间趋势,应用SPSS 16.0软件、Joinpoint Regression Program 3.5.1统计软件进行生存分析.结果 2002-2010年上海市杨浦区新发肺癌5726例,其中男性3865例,女性1861例.男女发病年龄分别为(70.08±11.69)岁和(70.88±12.36)岁.肺癌男性平均粗发病率为77.36/10万,明显高于女性(39.31/10万；U=24.84,P＜0.01).肺癌男性标化发病率为25.23/10万,明显高于女性(13.47/10万；U=13.24,P＜0.01).2002-2010年上海市杨浦区死于肺癌患者5248例,其中男性3586例,女性1662例.肺癌男性平均粗死亡率为71.77/10万,明显高于女性(35.11/10万；U=24.67,P＜0.01).肺癌男性标化死亡率为21.72/10万,明显高于女性(11.08/10万；U=13.01,P＜0.01).45岁以后,男性与女性肺癌的发病率和死亡率均明显上升.5726例肺癌患者的1、2、3、4和5年生存率分别为37.42％、22.71％、15.73％、12.32％和10.53％,其中男性患者的1、2、3、4和5年生存率均明显低于女性患者(均P＜0.05)；手术切除组患者的1、2、3、4和5年生存率均明显高于非手术组患者(均P＜0.05).结论 上海市杨浦区肺癌的发病率与死亡率接近,男性发病率和死亡率均高于女性,手术治疗可改善肺癌患者的预后.

abstractsObjective To analyze the incidence and mortality of lung cancer patients among residents in Yangpu District of Shanghai from 2002 to 2010.Methods The data of lung cancer cases in permanent residents of Yangpu district were collected from the database of the registration and management system in Shanghai city.Temporal trend in the incidence of lung cancer was analyzed by using annual percent change (APC) model.The survivals were calculated using SPSS 16.0 and Joinpoint Regression Program 3.5.1 software.Results A total of 5726 cases of lung cancer were diagnosed from January 2002 to December 2010.Of those,3865 were males with an average age of onset 70.08 years,and 1861 were females with an average age of onset 70.88 years.The crude incidence rate was 77.36/105 in men,significantly higher than 39.31/105 in women (U =24.84,P ＜0.01).The standardized incidence rate was 25.23/105 in men,significantly higher than 13.47/105 in women (U =13.24,P ＜ 0.01).A total of 5248cases died of the disease in this period.Of those,3586 were men.The crude mortality was 71.77/105 in men,significantly higher than 35.11/105 in women (U =24.67,P ＜ 0.01).The standardized mortality was 21.72/105 in men,significantly higher than 11.08/105 in women (U =13.01,P ＜ 0.01).Both the incidence and mortality rates increased apparently in those older than 45 years.The 1-to 5-year survival rates in all cases were 37.42％,22.71％,15.73％,12.32％,and 10.53％,respectively.The 1-to 5-year survival rates in male cases were significantly lower than those in female cases (P ＜ 0.05 for each comparison).The 1-to 5-year survival rates of the patients whose tumor had been surgically removed were significantly higher than those in the patients without surgery (P ＜ 0.05 for each comparison).Conclusions The incidence of lung cancer is close to the mortality in the residents of Yangpu District of Shanghai city.Surgical resection treatment improves the prognosis of lung cancer.