摘要随着局部晚期非小细胞肺癌（ LA-NSCLC）的局部控制率和生存率的提高，脑转移所致治疗失败这一临床难题日益突出。预防性全脑照射（ PCI）已被证实能够降低完全缓解的小细胞肺癌脑转移患者的发生率、提高其生存率，但PCI在LA-NSCLC治疗中的意义仍有争议。阐述PCI 在LA-NSCLC的作用、获益人群、不良反应、PCI的剂量及时机，以期为制订局部晚期非小细胞肺癌的临床策略提供依据。

abstractsAs multi-modality treatments are now able to ensure better local control and a lower rate of extra-cranial metastasis, brain metastasis has become a major concern in locally advanced non-small cell lung cancer (LA-NSCLC).Prophylactic cranial irradiation (PCI) is now a standard treatment for patients with small cell lung cancer ( SCLC ) , it decreases the incidence of brain metastases and increases the survival rate.Despite the relatively high incidence of brain metastases in LA-NSCLC, the role of PCI in patients treated with radical intent has not been established yet.The objective of this systematic review was to establish whether PCI prevents the development of brain metastasis and increases survival in LA-NSCLC patients, the characteristics of the benefit patients, the tolerance and toxicity, the effective dose and timing of PCI.The main concern in this review is to establish the definitive role of PCI in the treatment of locally advanced NSCLC.