摘要原发性肝癌的主要病理类型是肝细胞癌( HCC),其病因相对清楚,慢性乙肝病毒感染是我国高发区HCC的主要病因,其次为黄曲霉毒素暴露.在江苏省启东市开展的肝癌一级预防干预措施中,新生儿期接种乙肝疫苗对＜30岁人群肝癌发病的保护率为84%(95% CI为23%～97%);清洁饮水和降低黄曲霉毒素暴露后,＜35岁人群的肝癌发病风险与30年前比较,降低至少4倍.清洁水源、防霉改粮、预防乙型肝炎病毒感染是农村高发区有效的肝癌一级预防模式.

abstractsHepatocellular carcinoma ( HCC) is the major histological type of primary liver cancer (PLC), and the etiology is relative clear. Chronic infection of hepatitis B virus (HBV) plays dominant roles, and high exposure to aflatoxins is an important co-factor.Qidong was one of the endemic area with high PLC incidence in rural China. The results from a series of etiological intervention studies on PLC in this area indicated that 1) the protective efficacy of neonatal HBV vaccination against PLC development under the age of 30 was 84%(95% CI 23%-97%); 2) the relative risk of liver cancer incidence decreased at least 4 folds in young adults aged＜35 years with reducing aflatoxin exposures and cleaning drinking water.The prevention of HBV infection and the supplies of clean water and safe food with limited aflatoxins demonstrated as an effective primary prevention model of liver cancer in rural China.