摘要目的:探讨保乳术联合术中放疗治疗早期乳腺癌的近期疗效及安全性。方法:回顾性分析101例接受保乳术联合术中放疗的早期乳腺癌患者的临床病理资料及近期随访结果，采用单因素分析方法和多因素Logistic回归模型分析术后不良反应及乳房美容效果的影响因素。结果:101例患者中，4例出现复发或转移，术后3年无病生存率为94.9%，3年累积复发率为5.1%。单因素分析显示，月经状态和术后全乳放疗与术后不良反应发生有关(均 P<0.05)，T分期和施源器直径与乳房美容效果有关(均 P<0.05)。多因素分析显示，施源器直径( OR＝3.701， P＝0.026)和术后全乳放疗( OR＝5.962， P＝0.005)是术后不良反应发生的独立影响因素，施源器直径( OR＝2.522， P＝0.037)是乳房美容效果的独立影响因素。 结论:保乳术联合术中放疗治疗低危的早期乳腺癌具有较好的近期疗效和安全性。

abstractsObjective:To analyze the safety and short-term efficacy of breast-conserving surgery combined with intraoperative radiotherapy for early-stage breast cancer.Methods:A total of 101 consecutive patients who received breast-conserving surgery plus intraoperative radiotherapy were recruited to summarize the recent follow-up results and clinicopathological data. Univariate analysis and Logistic regression model were used to evaluate the factors affecting the postoperative adverse reactions and cosmetic effects.Results:Among 101 patients, 4 patients had recurrence or metastasis. The 3-years disease free survival rate was 94.9%, and the 3-years cumulative recurrence rate was 5.1%. Univariate analysis showed that the menstrual status and postoperative whole breast radiotherapy were associated with the postoperative adverse reactions ( P<0.05). The T stage and applicator diameter were associated with the cosmetic effect ( P<0.05). Multivariate analysis indicated that the diameter of the applicator ( OR=3.701, P=0.026) and postoperative whole breast radiotherapy ( OR=5.962, P=0.005) were independent factors for the postoperative adverse reactions, and the diameter of the applicator ( OR=2.522, P=0.037) was an independent factor for the cosmetic effect. Conclusion:Breast-conserving surgery combined with intraoperative radiotherapy shows safety and good short-term efficacy in low-risk early-stage breast cancer.