换一批摘要Enlightened by the law of interactions among objects in the physical world, we propose a heuristic algorithm for solving the three-dimensional (3D) off-lattice protein folding problem. Based on a physical model, the problem is converted from a nonlinear constraint-satisfied problem to an unconstrained optimization problem which can be solved by the well-known gradient method. To improve the efficiency of our algorithm, a strategy was introduced to generate initial configuration. Computational results showed that this algorithm could find states with lower energy than previously proposed ground states obtained by nPERM algorithm for all chains with length ranging from 13 to 55.
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分类号
TP3Q67（物理化学生物学）
发布时间
2006-03-16（万方平台首次上网日期，不代表论文的发表时间）
基金项目
科技部科研项目（2004CB318000）
中国科学院项目（非规范项目）（10471051）
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