Solid lipid nanoparticles loading adefovir dipivoxil for antiviral therapy

二维码有效期 120s

摘要Herein, solid lipid nanoparticles (SLN) were proposed as a new drug delivery system for adefovir dipivoxil (ADV). The octadecylamine-fluorescein isothiocynate (ODA-FITC) was synthesized and used as a fluorescence maker to be incorporated into SLN to investigate the time-dependent cellular uptake of SLN by HepG2.2.15. The SLN of monostearin with ODA-FITC or ADV were prepared by solvent diffusion method in an aqueous system. About 15wt% drug entrapment efficiency (EE) and 3wt% drug loading (DL) could be reached in SLN loading ADV. Comparing with free ADV, the inhibitory effects of ADV loaded in SLN on hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg) and hepatitis B virus (HBV) DNA levels in vitro were significantly enhanced.

作者单位 Department of Pharmacy, the First Affiliated Hospital School of Medicine, Zhejiang University, Hangzhou 310003, China ^[1] Department of Pharmacy, the First Affiliated Hospital School of Medicine, Zhejiang University, Hangzhou 310003, China;State Key Lab for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou 310003, China ^[2] College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China ^[3]

关键词 Adefovir dipivoxil (ADV)Solid lipid nanoparticles (SLN)Octadecylamine-fluorescein isothiocynate (ODA-FITC)Hepatitis B virus (HBV)

分类号 R512.6+2 R943 R978.7

栏目名称 Science Letters

发布时间 2008-07-23

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