透明质酸衍生物修饰脂质纳米载体的抗肿瘤作用及体内靶向研究

Hyaluronic acid derivative-modified nano-structured lipid carrier for cancer targeting and therapy#

摘要目的:以脂质纳米载体为递药系统向肿瘤部位靶向输送难溶性抗肿瘤药物紫杉醇,实现药物的靶向递送.创新点:采用一端疏水化的透明质酸修饰脂质纳米载体,利用透明质酸与肿瘤部位高表达CD44的特异性结合,实现载药脂质纳米粒的靶向输送.方法:通过酰胺反应,将硬脂胺化学嫁接至透明质酸,制备透明质酸-硬脂胺嫁接物.采用水性溶剂扩散法制备脂质纳米粒,并将透明质酸-硬脂胺嫁接物插入脂质纳米粒的表面.使用红外染料DiR标记脂质纳米粒,通过小动物活体成像技术观察标记脂质纳米粒的体内分布.结论:透明质酸修饰的脂质纳米粒,可通过与CD44的特异性结合,实现抗肿瘤药物的靶向递送.

作者单位 Department of Pharmacy, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China ^[1] Department of Radiotherapy, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China ^[2] Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston TX 77030, USA ^[3]

关键词紫杉醇透明质酸-硬脂胺纳米结构脂质载体肿瘤靶向体内分布 Paclitaxel (PTX)Hyaluronic acid-octadecylamine (HA-ODA)Nano-structured lipid carrier (NLC)Tumor targeting In vivo distribution

分类号 R94 TB383

栏目名称 Articles

发布时间 2020-07-15

基金项目

the Zhejiang Provincial Natural Science Founda-tion of China

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