摘要The dysfunction of the lysosome and autophagy-lysosome system serves as a driving force for neurodegenerative diseases,metabolic disorders,inflammatory conditions,and other related diseases,closely influencing their onset and progression.Therefore,restoring the function of the lysosome or autophagy-lysosome system has become an increasingly crucial therapeutic strategy in disease management.In this review,we will introduce the lysosomal biogenesis,structure,and function,as well as the biological process of the autophagy-lysosome system.Various diseases closely associated with lysosomal/autophagic dysfunction are also reviewed,emphasizing the significance of targeting the function of the lysosome or autophagy-lysosome system in disease treatment.Finally,we focus on engineered nanomaterials that have the capabilities to restore the function of the lysosome or autophagy-lysosome system,and summarize different strategies and methods for achieving this goal.This review aims to elucidate the latest progress in the field of nanomedicine for lysosomal/autophagic defect-related diseases and inspire the development of innovative and clinically valuable nanomedicines.