首页 > 浙江大学学报（英文版）（B辑：生物医学和生物技术） > Recent research advances in the biological function and molecular mechanism of methylmalonic acid

Recent research advances in the biological function and molecular mechanism of methylmalonic acid

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学术成果认领

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摘要The abnormal accumulation of methylmalonic acid(MMA),the leading cause of methylmalonic acidemia,can cause irreversible damage to the brain,kidney,and cardiovascular system.In addition,the accumulation of MMA in the blood has recently been associated with the occurrence of cancer,restricted bodily movement,and growth retardation.In this review,recent studies on the relationship between the metabolic abnormality of MMA and disease occurrence were summarized,concerning the brain,kidney,cardiovascular system,cancer,and skeletal muscles.It provides a theoretical basis and reference for further research and the treatment of MMA-related pathophysiological changes.

作者 Zi'ang WANG ^[1] Wenhui CHENG ^[1] Teng WANG ^[1] Yidi ZHANG ^[1] Xin'e SHI ^[1] Yuqi LV ^[2] Jianjun JIN ^[1] 学术成果认领

作者单位 Laboratory of Animal Fat Deposition and Muscle Development,Key Laboratory of Animal Genetics,Breeding and Reproduction of Shaanxi Province,College of Animal Science and Technology,Northwest A&F University,Yangling 712100,China ^[1] College of Chemistry&Pharmacy,Northwest A&F University,Yangling 712100,China ^[2]

关键词 Methylmalonic acid(MMA)Mitochondrial dysfunction Oxidative stress Post-translational modification of protein Muscle atrophy

栏目名称

Reviews

DOI 10.1631/jzus.B2400202

发布时间 2026-03-26（万方平台首次上网日期，不代表论文的发表时间）

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