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The pathways and the mechanisms by which Cryptococcus enters the brain

摘要Generally,Cryptococcus initially infects the respiratory tract,but can spread,eventually crossing the blood-brain barrier(BBB)and causing meningitis or meningoencephalitis.Specifically,Cryptococcus invades the vascular endothelial cells of the BBB,from which it enters the brain.The main mechan-isms through which Cryptococcus crosses the BBB are transcellular traversal,the paracellular pathway,and via Trojan horse.In this paper,the mechanisms by which Cryptococcus crosses the BBB were explained in detail.In addition to pathways of entry to the brain,this paper presents a discussion on some rare cryptococcal infections and provides some insights for future research directions.

作者 Yangyu Zhou ^[1] Yemei Huang ^[1] Chen Yang ^[2] Xuelei Zang ^[1] Hengyu Deng ^[3] Jing Liu ^[3] Enqi Zhao ^[1] Tingyue Tian ^[1] Lei Pan ^[1] Xinying Xue ^[4] 学术成果认领

作者单位 Department of Respiratory and Critical Care,Emergency and Critical Care Medical Center,Beijing Shijitan Hospital,Capital Medical University,Beijing,China ^[1] Department of Respiratory and Critical Care,Weifang Medical College,Weifang,China ^[2] Department of Laboratory Medicine,Chinese PLA General Hospital,the First Medical Centre,Beijing,China ^[3] Department of Respiratory and Critical Care,Emergency and Critical Care Medical Center,Beijing Shijitan Hospital,Capital Medical University,Beijing,China;Department of Laboratory Medicine,Chinese PLA General Hospital,the First Medical Centre,Beijing,China ^[4]

关键词 Cryptococcus blood-brain barrier transcellular traversal paracellular pathway trojan horse mechanism

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DOI 10.1080/21501203.2023.2295409

发布时间 2025-06-18（万方平台首次上网日期，不代表论文的发表时间）