摘要乳腺基底细胞样癌(BLBC)是根据基因表达模式分离出的一类乳腺癌亚型,具有独特的哪组织学形态及生物学行为.这类肿瘤通常呈三联阴性(TG)且表达基底细胞型细胞角蛋白(basal CK),侵袭性强.现就BLBC的镜下特征、临床进展、预后及化疗反应等进行综述,便于临床及病理医师更好地认识这类疾病.

abstractsBasal-like breast carcinoma is a phenotype of breast cancer which was sub-classified according to gene expression profiling criteria, associated with specific pathological features and biological behaviour. These cancer used to be more aggressive and characterized by the absent expression of ER/PR/CerbB-2(triple negative, TG) however positive for basal cytokeratins(basal CK). We present this review to show its pathological characters, clinical progression, prognosis and response to chemotherapy, and provide convenience for pathologists and surgical colleagues be more aware of this subtype.