摘要目的 探讨FoxM1和c-myc蛋白在基底细胞样型乳腺癌(BLBC)、非基底细胞样型乳腺癌(non-BLBC)及癌旁正常乳腺组织中的表达情况及二者之间的相互关系.方法 采用免疫组织化学法检测66例BLBC及其癌旁正常乳腺组织、70例non-BLBC组织FoxM1和c-myc蛋白的表达情况,采用Spearman相关分析法分析其与病理临床特征的关系.结果 BLBC、non-BLBC及癌旁正常乳腺组织中FoxM1蛋白阳性表达率分别为77.3％(51/66)、60.0％(42/70)和13.6％(9/66),c-myc蛋白阳性表达率分别为71.2％(47/66)、54.3％(38/70)和22.7％(15/66),FoxM1和c-myc蛋白在BLBC和non-BLBC组织中表达率均明显高于癌旁正常乳腺组织,且在BLBC组织中的表达明显高于non-BLBC组织,差异均有统计学意义(均P＜ 0.05).在BLBC中FoxM1和c-myc蛋白表达呈正相关(r=0.294,P＜ 0.05),且FoxM1和c-myc蛋白的表达与BLBC淋巴结转移及临床分期有关(P＜0.05).结论 FoxM1和c-myc蛋白参与了BLBC的发生、发展,并且FoxM1和c-myc蛋白有一定的协同作用.

abstractsObjective To detect the protein expressions of FoxM1 and c-myc in basal-like breast carcinoma and explore their correlation.Methods The expression of FoxM1 and c-myc was detected in 66 cases of BLBC,70 cases of non-BLBC and 66 cases of normal adjacent breast tissue by immunohistochemistry.The relationship of them was analyzed.Rusults The expression rates of FoxM1 and c-myc protein in BLBC [77.3 ％ (51/66),71.2 ％ (47/66)] was significant increased than that in normal breast tissue [13.6 ％ (9/66),22.7 ％ (15/66)],and higher than that in non-BLBC [60.0 ％ (42/70),54.3 ％ (38/70)].The expression of FoxM1 and c-myc positively correlated with lymph nodes metastasis and TNM staging of BLBC (P ＜ 0.05).Positive expressions correlation could be found between the expression of FoxM1 and that of c-myc as well (r =0.294,P ＜ 0.05).Conclusion FoxM1 and c-myc may play important roles in the carcinogenesis and development of BLBC and the study supports the positive feedback effect between the expressions of FoxM1 and c-myc furthermore.