摘要目的：研究绝经前乳腺癌患者术后辅助化疗对月经的影响。方法对2010年1月至2012年12月收治的120例≤45岁绝经前乳腺癌患者进行跟踪随访，回顾性分析绝经前乳腺癌患者术后化疗致闭经（CIA）的发生率、闭经持续时间及闭经恢复率等情况。分析不同年龄组、不同化疗方案患者的 CIA 发生情况。结果120例≤45岁绝经前乳腺癌患者， CIA 发生率为78.3%（94／120），≤35岁患者 CIA 的发生率明显低于＞35岁患者（P＜0.05），出现 CIA 的94例患者中，有50例（53.2%）恢复月经，不同年龄组患者 CIA 的恢复差异均有统计学意义（均 P＜0.05）。术后蒽环类药物化疗组与蒽环类药物联合紫杉类药物化疗组 CIA 发生率差异无统计学意义（P＞0.05）。结论年龄是化疗诱导闭经的重要影响因素，年龄≤35岁的患者月经受化疗影响较小，闭经多可逆。化疗方案中序贯加用紫杉类药物与单用蒽环类药物对月经影响无明显差异。

abstractsObjective To study the influence of postoperative chemotherapeutic regimens on menstruation in pre-menopausal patients with breast cancer. Methods 120 pre-menopausal patients with breast cancer from Jan 2010 to Dec 2012 were followed-up. The occurrence rate and recovery rate of chemotherapy-induced amenorrhea (CIA) were analyzed. The relationship between different chemotherapeutic regimens and CIA of various age groups was analyzed. Results 120 women were followed-up, 94 (78.3 %) patients developed CIA. The frequency of CIA in younger patients (≤ 35 years) was significantly lower than that in patients older than 35 years (P < 0.05). 50 (53.2 %) patients returned to normal menses. The recovery situation of CIA was significantly different among various age groups (P < 0.05). The difference of the occurrence rate of CIA was not statistically significant between the patients who received anthracycline-based chemotherapy and docetaxel-based chemotherapy (P > 0.05). Conclusions Age is an important influence factor of the CIA. Chemotherapy has less influence on the menstruation of younger patients (≤35 years) and most amenorrhea is reversible. The effects of sequential addition of taxanes in chemotherapy and anthracyclines alone on menstruation have no significant difference.