摘要RECK蛋白在正常细胞和组织中表达量很高,但在发生恶转的细胞和肿瘤组织中表达下调,后续的功能研究证明RECK具有肿瘤抑制功能,因此阐明支配细胞内RECK基因表达的调控机制显得尤为重要.表观调控在调节体内基因表达过程中发挥了重要的作用,而且众多研究也表明RECK基因受表观调控.文章综述到目前为止发现的能够表观调控RECK基因表达的机制.

abstractsThe RECK protein is highly expressed in normal cells and tissues,however,down-regulated in transformed cells or tumor tissues.Subsequent functional studies have demonstrated that RECK owns the tumor suppressor activity.Hence,it is urgent and important to unmask the mechanisms involved in regulation of RECK expression.Epigenetic regulation plays a vital role in modulating gene expression,besides,multiple research also suggested the involvement of epigenetic regulation in RECK expression.The epigenetic regulation mechanisms of controlling the gene expression currently known will be reviewed in this paper.