摘要近年来溶瘤病毒在肿瘤治疗方面取得了较大突破,尤其是呼肠孤病毒,可有效地诱导肿瘤细胞凋亡而不损害正常机体组织,超过80％的肿瘤细胞对呼肠孤病毒感染敏感.呼肠孤病毒主要通过诱导肿瘤细胞凋亡,发挥抗肿瘤免疫作用来实现其抗肿瘤活性,同时呼肠孤病毒与化疗药物的联合作用远超过单药治疗的效果,并且可通过不同的作用机制发挥抗肿瘤作用,对未来肿瘤的新型高效治疗有重大意义.

abstractsOncolytic viruses have made great breakthroughs in cancer treatment, especially for reovirus, which can effectively induce the death of tumor cells without harming the normal tissues. More than 80％ tumor cells are sensitive to reovirus infection. Reovirus induces the apoptosis of tumor cells and exerts anti-tumor immunity to achieve anti-tumor activity, and the curative effect of combination therapy with reovirus and chemotherapeutic drugs exceeds the effect of monotherapy. Reovirus can exert anti-tumor effects through different mechanisms, which is of great significance for the new and effective treatment of tumors in the future.