摘要目的 探讨恶性肿瘤家族史(MN-FH)与非小细胞肺癌(NSCLC)患者临床病理特征之间的关系.方法 回顾性分析扬州大学附属医院2016年6月至2018年6月收治的326例NSCLC患者的临床病理资料,根据有无MN-FH分成两组.采用 χ2检验分析两组临床病理特征之间的关系.结果 326例NSCLC患者中,有MN-FH 41例(12.6％),无MN-FH 285例(87.4％).有无MN-FH两组NSCLC患者间性别、年龄、吸烟、肿瘤发生部位、组织学分型的构成差异均无统计学意义(χ2值分别为0.031、0.769、0.546、0.117、0.945,均P>0.05),但有MN-FH组肿瘤直径<5 cm[65.9％(27/41)比42.5％(121/285),χ2=14.173,P<0.05]、未分化+低分化[70.7％(29/41)比53.7％(153/285),χ2=4.224,P<0.05]、TNM分期Ⅲ+Ⅳ期[65.9％(27/41)比46.7％(133/285),χ2=5.280,P<0.05]、淋巴结转移[78.0％(32/41)比60.0％(171/285),χ2=4.970,P<0.05]、远处转移[75.6％(31/41)比53.3％(152/285),χ2=7.224,P<0.05]、高恶性程度[70.7％(29/41)比51.6％(147/285),χ2=5.293,P<0.05]、合并其他肿瘤[29.3％(12/41)比7.7％(22/285),χ2=17.817,P<0.05]比例均高于无MN-FH组.结论 有MN-FH的NSCLC患者肿瘤恶性程度较高.对于有MN-FH的人群体检十分重要.

abstractsObjective To discuss the correlation between family history of malignant neoplasms (MN-FH) and the clinicopathological features of patients with non-small cell lung cancer (NSCLC). Methods The clinicopathological data of 326 patients with NSCLC in Yangzhou University Affiliated Hospital from June 2016 to June 2018 were analyzed retrospectively. The patients were divided into two groups based on with or without MN-FH, and the clinicopathological features of the two groups were analyzed by χ 2 test. Results Of the 326 patients with NSCLC, 41 (12.6％) were in the MN-FH group and 285 (87.4％) in the MN-FH group. There were no significant differences in sex, age, smoking, location of tumors and histological classification between patients with or without MN-FH (χ 2 values were 0.031, 0.769, 0.546, 0.117, and 0.945, all P > 0.05), but in patients with MN-FH, the proportion of tumor diameter < 5 cm [65.9％ (27/41) vs. 42.5％(121/285), χ 2 = 14.173, P < 0.05], undifferentiation and low differentiation [70.7％ (29/41) vs. 53.7％(153/285), χ 2 = 4.224, P < 0.05], TNM stage Ⅲ+Ⅳ [65.9％ (27/41) vs. 46.7％ (133/285), χ 2 = 5.280, P <0.05], lymph node metastasis [78.0％ (32/41) vs. 60.0％ (171/285), χ 2 = 4.970, P < 0.05], distant metastasis [75.6％ (31/41) vs. 53.3％ (152/285), χ 2 = 7.224, P < 0.05], high degree of malignancy [70.7％ (29/41) vs. 51.6％ (147/285), χ 2 = 5.293, P < 0.05] and combination of other tumors [29.3％ (12/41) vs. 7.7％ (22/285),χ 2 = 17.817, P < 0.05] were significantly higher than those in patients without MN-FH. Conclusions NSCLC patients with MN-FH have a higher degree of malignancy. For people with MN-FH, physical examination is very important.