摘要放疗既可通过对照射野内肿瘤细胞的杀伤来提高肿瘤的局部控制率,也可通过多种机制激活机体抗肿瘤免疫应答来降低远处播散,在免疫治疗的辅助下协同发挥全身抗肿瘤作用.作为一种新的联合治疗方式,目前有大量研究发现局部放疗与不同免疫制剂联合治疗后使得肿瘤患者生存获益.联合治疗的最佳疗效与合适的放疗剂量、分割模式及联合时机等因素密切相关.文章就放疗对机体免疫系统的影响、肿瘤放疗与免疫治疗联合的相关基础和临床研究以及如何进行有效结合进行综述.

abstractsRadiotherapy can improve the local control rate of the tumors by destructing the tumor cells within the radiation field, can reduce the distant spread by activating the body 's anti-tumor immune response through various mechanisms, and also can exert systemic anti-tumor effect synergistically assisted by immunotherapy. As a new combination therapy, a large number of studies have found that local radiotherapy combined with different immunotherapy can benefit the survival of cancer patients. The optimal efficacy is closely related to the appropriate radiotherapy dose, segmentation model and combined timing. This paper discusses the effects of radiotherapy on the immune system, the related basic and clinical researches of radiotherapy and immunotherapy, and the better way to make the combination effectively.