摘要Genotype-environment interaction(G × E)models have potential in digital breeding and crop phenotype pre-diction.Using genotype-specific parameters(GSPs)as a bridge,crop growth models can capture G × E and simulate plant growth and development processes.In this study,a dataset containing multi-environmental planting and flowering data for 169 genotypes,each with 700K single nucleotide polymorphism(SNP)markers was used.Three rice growth models(ORYZA,CERES-Rice,and RiceGrow),SNPs,and climatic indices were in-tegrated for flowering time prediction.Significant associations between GSPs and quantitative trait nucleotides(QTNs)were investigated using genome-wide association study(GWAS)methods.Several GSPs were associated with previously reported rice flowering genes,including DTH2,DTH3 and OsCOL15,demonstrating the genetic interpretability of the models.The rice models driven by SNPs-based GSPs showed a decrease in goodness of fit as reflected by increased root mean square errors(RMSE),compared to the traditional model calibration.The predictions of crop model were further modified using the machine learning(ML)methods and climate indicators.The accuracy of the modified predictions were comparable to what was achieved using the traditional calibration approach.In addition,the Multi-model ensemble(MME)was comparable to that of the best individual model.Implications of our findings can potentially facilitate molecular breeding and phenotypic prediction of rice.