Diversity, structure and function of the coiled-coil domains of plant NLR immune receptorsFA

二维码有效期 120s

摘要Plant nucleotide-binding, leucine-rich repeat receptors (NLRs) perceive pathogen avirulence effectors and activate defense responses. Nucleotide-binding, leucine-rich repeat re-ceptors are classified into coiled-coil (CC)-containing and Toll/interleukin-1 receptor (TIR)-containing NLRs. Recent advances sug-gest that NLR CC domains often function in signaling activation, especially for induction of cell death. In this review, we outline our current understanding of NLR CC domains, including their diversity/classification and structure, their roles in cell death induction, disease resist-ance, and interaction with other proteins. Fur-thermore, we provide possible directions for future work.

作者 Junzhu Wang ^[1] Meng Han ^[1] Yule Liu ^[1] 学术成果认领

作者单位 MOE Key Laboratory of Bioinformatics, Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China;Tsinghua-Peking Center for Life Sciences, Beijing 100084, China ^[1]

关键词 cell death classification coiled-coil domain disease resistance NLR structure

栏目名称 Invited Expert Review

发布时间 2021-03-19

基金项目

This work was supported by the National Natural Science Foundation of China

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