摘要Lipid droplet(LD)in vegetative tissues has re-cently been implicated in environmental re-sponses in plants,but its regulation and its function in stress tolerance are not well under-stood.Here,we identified a Membrane Occu-pation and Recognition Nexus 1(MORN1)gene as a contributor to natural variations of stress tolerance through genome-wide association study in Arabidopsis thaliana.Characterization of its loss-of-function mutant and natural var-iants revealed that the MORN1 gene is a positive regulator of plant growth,disease resistance,cold tolerance,and heat tolerance.The MORN1 protein is associated with the Golgi and is also partly associated with LD.Protein truncations that disrupt these associations abolished the biological function of the MORN1 protein.Fur-thermore,the MORN1 gene is a positive regu-lator of LD abundance,and its role in LD number regulation and stress tolerance is highly linked.Therefore,this study identifies MORN1 as a positive regulator of LD abundance and a con-tributor to natural variations of stress tolerance.It implicates a potential involvement of Golgi in LD biogenesis and strongly suggests a con-tribution of LD to diverse processes of plant growth and stress responses.