红姜叶提取物所含化学成分的抗肿瘤及抗菌作用

Leaf extract of Alpinia purpurata (Vieill.) K.Schum screened for its phytochemical constituents and antibacterial and anticancer activities

二维码有效期 120s

摘要目的:研究红姜叶提取物中的化学成分的抗肿瘤及抗菌活性.方法:用自来水充分洗净红姜叶,晾干后制成粉剂,用连续溶剂系统提取其化学成分.对植物化学成分进行评估,运用纸片扩散法检测植物提取物的抗菌活性,利用四甲基偶氮唑盐比色法检测植物叶子的乙酸乙酯提取物的抗肿瘤作用.结果:红姜叶经乙酸乙酯提取后,能最大限度得到有效的植物化学成分.不同浓度的红姜叶植物提取物抑制细菌的区域为5～14 mm;并且在48h内、植物提取物半数抑制浓度为110.25μg/mL时表现出抗PA1卵巢癌细胞株活性,且细胞数量呈剂量依赖性递减.结论:红姜叶的乙酸乙酯提取物中的化学成分可有效抑制细菌活性,并具有抗肿瘤的作用.

作者 Chinthamony Arul Raj ^[1] Dominic Sophia ^[1] Paramasivam Ragavendran ^[1] Thangarajan Starlin ^[2] Muthian Ahalliya Rathi ^[3] Velliyur Kanniappan Gopalakrishnan ^[4] 学术成果认领

作者单位 Department of Biochemistry,Karpagam University,Coimbatore 641021,Tamilnadu,India ^[1] Department of Bioinformatics,Karpagam University,Coimbatore 641021,Tamilnadu,India ^[2] Department of Biochemistry,Sree Narayana Guru College,Coimbatore 641105,Tamilnadu,India ^[3] Department of Biochemistry,Karpagam University,Coimbatore 641021,Tamilnadu,India;Department of Bioinformatics,Karpagam University,Coimbatore 641021,Tamilnadu,India ^[4]

关键词山姜属植物提取物抗菌药抗肿瘤药体外研究 Alpinia plant extracts antibacterial agents antineoplastic agents in vitro

主题词化学(Chemistry)肿瘤(Neoplasms)植物提取物(Plant Extracts)山姜属(Alpinia)抗菌药(Anti-Bacterial Agents)

栏目名称 实验论著

DOI 10.3736/jcim20121219

发布时间 2013-02-01