摘要The widespread use of opioids to treat chronic pain led to a nation-wide crisis in the United States.Tens of thousands of deaths annually occur mainly due to respiratory depression,the most dangerous side effect of opioids.Non-opioid drugs and non-pharmacological treatments without addictive potential are urgently required.Traditional Chinese medicine (TCM) is based on a completely different medical theory than academic Western medicine.The scientific basis of acupuncture and herbal treatments as main TCM practices has been considerably improved during the past two decades,and large meta-analyses with thousands of patients provide evidence for their efficacy.Furthermore,opinion leaders in the United States favor non-pharmacological techniques including TCM for pain management to fight the opioid crisis.We advocate TCM as therapeutic option without addictive potential and without life-threatening side effects (e.g.,respiratory depression) to treat chronic pain patients suffering from opioid misuse.The evidence suggests that:(1) opioid misuse cannot be satisfactorily managed with standard medication;(2) opinion leaders in the United States favor to consider non-opioid and non-pharmacological treatment strategies including those from TCM to treat acute and chronic pain condi-tions;(3) large meta-analyses provide scientific evidence for the clinical activity of acupuncture and her-bal TCM remedies in the treatment of chronic pain.Future clinical trials should demonstrate the safety of TCM treatments if combined with Western medical practices to exclude negative interactions between both modalities.