摘要Acquired immune deficiency syndrome(AIDS)is a worldwide epidemic caused by human immunodefi-ciency virus(HIV)infection.Newer medicines for eliminating the viral reservoir and eradicating the virus are urgently needed.Attempts to locate relatively safe and non-toxic medications from natural resources are ongoing now.Natural-product-based antiviral candidates have been exploited to a limited extent.However,antiviral research is inadequate to counteract for the resistant patterns.Plant-derived bioactive compounds hold promise as powerful pharmacophore scaffolds,which have shown anti-HIV potential.This review focuses on a consideration of the virus,various possible HIV-controlling methods and the recent progress in alternative natural compounds with anti-HIV activity,with a particular emphasis on recent results from natural sources of anti-HIV agents.