摘要Objective:To explore the association between acupuncture during controlled ovarian hyperstimulation(COH)and the live birth rate(LBR)using different propensity score methods.Methods:In this retrospective cohort study,eligible women who underwent a COH were divided into acupuncture and non-acupuncture groups.The primary outcome was LBR,as determined by propensity score matching(PSM).LBR was defined as the delivery of one or more living infants that reached a ges-tational age over 28 weeks after embryo transfer.The propensity score model encompassed 16 confound-ing variables.To validate the results,sensitivity analyses were conducted using three additional propensity score methods:propensity score adjustment,inverse probability weighting(IPW),and IPW with a"doubly robust"estimator.Results:The primary cohort encompassed 9751 patients(1830[18.76％]in the acupuncture group and 7921[81.23％]in the non-acupuncture group).Following 1∶1 PSM,a higher LBR was found in the acupuncture cohort(41.4％[755/1824]vs 36.4％[664/1824],with an odds ratio of 1.23[95％confidence interval,1.08-1.41]).Three additional propensity score methods produced essentially similar results.The risk of serious adverse events did not significantly differ between the two groups.Conclusion:This retrospective study revealed an association between acupuncture and an increased LBR among patients undergoing COH,and that acupuncture is a safe and valuable treatment option.