摘要The impact of the interaction of all combined environmental agents to which an individual is exposed during his/her lifetime, as well as how his/her organism responds to these influences, defines health, aging, and disease. The systematic, integrative characterization of the different elements making up the "exposome" is thus necessary to identify and exploit the potential of compounds capable of conferring protection with minimal side effects. Extracts from the natural world, containing synergistic combinations of compounds with antioxidant and protective properties, have long been used in traditional medicine. Modern science has the opportunity to leverage these substances honed by evolution and use them safely and reliably, with a profound mechanistic knowledge and guaranteeing standardization and absence of toxicity. Here, we discuss our current knowledge regarding the potential of a soluble extract of the hair grass Deschampsia antarctica (as its standardized commercial preparation Edafence?) to counteract the skin exposome and its impact on skin aging and disease.