摘要目的 探讨慢性乙肝重叠戊型肝炎病毒(HEV)急性感染的临床特点.方法 将78例慢性乙肝重叠HEV感染(简称戊乙肝)与单纯HEV感染进行对照研究.结果 78例戊型肝炎均为急性起病.平均年龄(46±17)岁,其中戊乙肝35例,单纯戊肝43例,男女比例2.39:1.戊乙肝组总胆红素(256±141μmol/L),肝性脑病发生率(14.3%),重型肝炎发生率(40.0%),明显高于单纯戊肝(P<0.05).结论 慢性乙肝重叠HEV急性感染易导致慢性乙型肝炎活动,易发生重型肝炎,病死率高,预后差.

abstractsObjective To explore the clinical features of patients with chronic hepatitis B virus(HBV) superinfected with hepatitis E virus(HEV). Methods The clinical characteristic of the patients with HBV and HEV superinfection were compared with those simple HEV infection. Results Totally 78 hepatitis E cases were all acute attacked with an average of (46±17) years old and the ratio of male to female was 2.39: 1. The 35 cases of them were HBV/HEV superinfection ,the other 43 cases were the simple hepatitis E. In the HBV/HEV superinfection group the level of total serum bilirubin was (256±141 )μmol/L,the hepatic encephalopathy rate was 14.3% ,the severe hepatitis rate was 40.0%, obviously more than that in the simple hepatitis E group( P <0.05).Conclusion Superinfection of HBV and HEV can cause chronic and more severe hepatitis, the poorer prognosis.