摘要目的 评估序贯疗法治疗幽门螺杆菌(Hp)阳性十二指肠溃疡的疗效与安全性.方法 选取70例经胃镜检查确诊且1个月内14C尿素呼气试验阳性的十二指肠溃疡患者,随机分为两组:治疗组前5 d给予雷贝拉唑、阿莫西林,后 5 d给予雷贝拉唑、替硝唑、克拉霉素治疗;对照组予雷贝拉唑加阿莫西林、克拉霉素治疗7 d.两组均继续予雷贝拉唑治疗3周,记录用药后患者症状缓解情况.疗程结束1个月后复查胃镜并行14C尿素呼气试验检测.结果 治疗组Hp根除率为94.1%,对照组根除率为77.8%,两组比较差异有统计学意义(P<0.05);治疗组症状缓解率为94.1%,溃疡治愈率为91.2%,对照组症状缓解率为88.9%,溃疡治愈率为86.1%,但两组间差异无统计学意义(P>0.05).两组不良反应发生率比较差异无统计学意义(P>0.05).结论 序贯疗法治疗Hp阳性十二指肠溃疡具有疗效高、耐受性和依从性好等优点.

abstractsObjective To evaluate the efficacy and safety of sequential therapy in the treatment of duodenal ulcer complicated with Helicobacter pylori(Hp). Methods Seventy patients with Hp positive duodenal ulcer were randomly divided into two groups. The treatment group were treated with rabeprazole,amoxillin at first five days; rabeprazole, clarithromycin and tinidazole at the second five days. The control group were treated with rabeprazole,amoxillin and clarithromycin for seven days. Two groups were treated with rabeprazole for 3 weeks sequentially. Gastroscopy and Hp test were performed in the fourth week after the end of the treatment. Results The Hp eradication rate was 94.1%in treatment group,while it was 77.8% in control group. There was significant difference between the two groups(P<0.05). The ulcer healing rate of treatment group was 91.2%, while it was 86.1% in control group.The symptomatic relief rate was 94.1% in treatment group, while it was 88.9% in control group. But there was no significant difference between the two groups(P>0.05). Conclusions Sequential therapy is more effective, well tolerated and with higher rate of eradication.