摘要目的 探讨妊娠高血压综合征(简称妊高征)患者的血凝与纤溶指标变化,为临床防治妊高征提供理论依据.方法 采用法国 STAGO全自动血凝分析仪测定,对妊高征患者(妊高征组)45例、正常妊娠组50例及同期健康体检女性50例(对照组)的凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(Fbg)及D-二聚体(DD) 进行检测分析.结果 正常妊娠组与对照组相比,正常妊娠组的PT和APTT下降,而Fbg和DD升高(P<0.05);妊高征组与正常妊娠组相比,妊高征组的PT和APTT进一步下降,Fbg和DD进一步升高(P<0.05).TT差异无统计学意义(P>0.05).结论 妊高征患者存在高凝状态及纤溶亢进,产前测定凝血功能及DD指标,对妊高征的预防及指导临床治疗具有重要意义.

abstractsObjective To explore the changes of hemagglutination and fibrinolysis parameter in pregnancy-induced hypertension syndrome, so as to provide theory for clinical therapy. Methods The level of PT,APTT,TT, Fbg and DD were detected by active hemagglutination analyzer in 45 patients with pregnancy-induced hypertension syndrome, 50 cases of normal pregnancy group, and 50 healthy subjects as controls. Results The levels of PT and APTT in normal pregnancy group were lower than that in normal control group(P<0.05), while the levels of Fbg and DD were higher than that in normal control group. To compare with normal pregnancy group, the levels of PT and APTT were further descend in patients with pregnancy-induced hypertension syndrome, while the levels of Fbg and DD were more higher(P<0.05). And the difference of TT was not statistically significant. Conclusions Pregnancy-induced hypertension syndrome patients may show up hypercoagulable state and fibrinolytic hyperactivity, to detecte the blood clotting function and DD in prenatal phase had important clinical significance to guide and prevent the pregnancy-induced hypertension syndrome.