摘要目的 观测2型糖尿病有、无慢性并发症及其心率变异(HRV)、QTc间期的变化.方法 2型糖尿病患者79例,根据临床检查区分各并发症,分为无并发症组(Ⅰ组17例)、冠心病组(Ⅱ组17例)、糖尿病肾病组(Ⅲ组15例)、糖尿病周围神经病变组(Ⅳ组17例)及多种并发症组(Ⅴ组13例)进行24 h动态心电图HRV分析及标准12导联心电图记录QTc间期.结果 ①2型糖尿病慢性并发症组QTc均＞0.44 s,且以冠心病组最为显效,但各组间比较差异无统计学意义(P＞0.05).②2型糖尿病慢性并发症组其HRV时域及频域指标明显低于无并发症组(P＞0.01).结论 2型糖尿病各种慢性并发症组其QTc间期延长、HRV下降,尤其在冠心病组中更为显著,提示该组存在潜在的高猝死风险.

abstractsObjective To study the variation of heart rate variability(HRV) and QTc interval in type 2 diabetes mellitus with or without chronic complications.Methods HRV and QTc interval was analyzed in 79 cases in type 2 diabetes mellitus.According to the clinical examinations,they were divided into no complication group ( group Ⅰ,17 cases),CHD group ( group Ⅱ,17 cases),diabetes nephropathy group (group Ⅲ,15 cases),diabetes periphral neuropathy group( group Ⅳ,17 cases)and multiple complications group ( group Ⅴ,13 cases).Results ①The QTc interval of CHD group was lengthen than any other groups.But it had no significant difference among the other groups ( P ＞ 0.05 ).②The HRV in diabetic patients with complication groups were significantly lower than those without complications ( P ＜ 0.01 ).Conclusions In the CHD group,the delay of QTc interval and the decreasing of HRV is more significant.It indicates that it has potential risk of sudden death.