摘要目的 探讨内生场局部热疗联合GP方案(泽菲、洛铂)化疗治疗晚期复治型胰腺癌的协同增效作用.方法 60例晚期胰腺癌患者均为经过一线化疗后复发患者,KPS评分60～ 70分,接受泽菲+洛铂,并在化疗的第2、5、9天接受肿瘤局部区域热疗,温度41 ～ 43℃,持续60 min.结果 60例中有效41例,疾病控制率为68.33％.不良反应以骨髓抑制及胃肠道反应为主,其中骨髓抑制以白细胞和血小板减少最为明显,胃肠道反应主要是恶心,占16.7％,发生呕吐者只占3.3％.其他与化疗相关的不良反应程度较轻,可耐受.结论 对于晚期胰腺癌患者,GP方案化疗联合热疗是一个较为安全的治疗方法,临床优势明显,逆转了耐药性,近期疗效高,能改善患者的生存质量.

abstractsObjective To investigate the synergistic effect of local endogenetic hyperthermia combined with GP ( Gemcitabine and Lobaplatin ) schemes in the treatment of patients with advanced pancreatic cancer.Methods Sixty patients with advanced pancreatic cancer were treated with chemotherapycombined with local hyperthermia.All the patients had progressed disease after first line chemotherapy with Karnofsky performance status (KPS) of 60 -70 and adequate organ function.The patients were treated with gemcitabine and Lobaplatin,and on day 2,5 and 9 during the chemotherapy,local radiofrequency hyperthermia was given at 41 -43 ℃ for continuous 60 minutes in tumor area.Results The disease control rate were 68.33％.The common side effects included gastrointestinal reactions and myelosuppression (leukocyte reduction and thrombocytopenia).Nausea was the main gastrointestinal reaction,accounting for 16.7％,vomiting accounting for only 3.3％.Other chemotherapy-related adverse reactions to a lesser extent and can be tolerated.Conclusions The local hyperthermia combined with GP regimen is effective and relatively safe for treatment of advanced pancreatic cancer.The regimen an enhance the response rate,improve patients'quality of life,and reverse drug resistance with high short-term efficacy.