摘要目的 探讨冠心病患者基质金属蛋白酶-9(MMP-9)和超敏C-反应蛋白(hs-CRP)水平及其与冠心病患者冠状动脉狭窄的相关性.方法 选取住院并进行冠状动脉造影检查的患者104例,按临床诊断分为稳定型心绞痛组26例、不稳定型心绞痛组30例以及急性心肌梗死组28例,冠脉造影正常组20例为对照组.所有入选患者于入院即刻抽取静脉血,测定各组MMP-9和hs-CRP水平差异；根据冠脉造影结果计算Gensini积分,并进行MMP-9和hs-CRP、Gensini积分相关分析.结果 急性心肌梗死组和不稳定型心绞痛组MMP-9和hs-CRP水平显著高于稳定型心绞痛组和对照组,差异有统计学意义(P＜0.05)；急性心肌梗死组高于不稳定型心绞痛组,差异有统计学意义(P＜0.05)；稳定型心绞痛组高于对照组,但差异无统计学意义(P＞0.05).各组MMP-9水平与Gensini积分呈显著正相关(r=0.697,P＜0.01),hs-CRP水平与Gensini积分呈显著正相关(r=0.813,P＜0.01),MMP-9浓度与hs-CRP浓度呈显著正相关(r=0.734,P＜0.01).结论 急性冠脉综合征患者MMP-9和hs-CRP水平显著高于稳定型心绞痛组和正常组,且与冠状动脉病变的严重程度有关,检测MMP-9和hs-CRP可作为评价冠心病患者危险程度的有用指标.

abstractsObjective To study the levels of serum MMP-9 and hs-CRP and their correlation with coronary artery lesions in patients with coronary heart disease.Methods One hundred and four patients in our hospital underwent the coronary angiography were selected.According to the diagnosis,all patients were divided into stable angina group in 26 cases,unstable angina group in 30 cases and acute myocardial infarction in 28 cases.At the same time,20 cases with normal coronary angiography were designated as control group.The venous blood samples were taken from the patients immediately after admission for detection of MMP-9 and hs-CRP.Gensini scores were calculated according to coronary angiography.The correlation of the level of MMP-9,hs-CRP with the Gensini score was compared and analyzed.Results The levels of serum MMP-9 and hs-CRP in AMI group and UAP group were significantly higher than those in SAP group and control group (P ＜ 0.05),and were higher in AMI group than those in UAP group (P ＜ 0.05),and were higher in SAP group than those in control group,but without statistical significance (P ＞0.05).The levels of serum MMP-9 in CHD groups were greatly correlated with Gensini score (r =0.697,P ＜0.01)and the levels of serum hs-CRP in CHD groups were greatly correlated with Gensini score(r =0.813,P ＜0.01).The levels of serum MMP-9 were greatly correlated with hs-CRP in CHD groups(r =0.734,P ＜ 0.01).Conclusions The levels of MMP-9 and hs-CRP in patients of ACS were much higher than those in SAP and control group and are correlated with coronary artery lesions.Combined detection of MMP-9 and hs-CRP can be used as useful indicators for forecasting major adverse cardiac events for coronary disease.