摘要目的 研究儿童新诊断的免疫性血小板减少症(ITP)血小板凋亡与幽门螺杆菌(Hp)的关系.方法 临床诊断明确的ITP患儿60例,其中13C阳性患儿30例,13C阴性患儿30例,采用流式细胞仪检测其血小板Caspase-3活性、磷脂丝氨酸(PS)外翻情况.结果 13C阳性患儿与13C阴性患儿相比,Caspase-3活性、PS外翻比较差异无统计学意义(P＞0.05).结论 新诊断的免疫性血小板减少症患儿血小板凋亡与幽门螺杆菌感染没有一定的关系.

abstractsObjective To study the relationship between platelet apoptosis in childhood newly diagnosed immune thrombocytopenia(ITP) and Helicobacter pylori(Hb).Methods Platelets were isolated from 30 patients with ITP,among them,there were 30 cases with positive 13C and 30 cases with negative 13C.Activation of Caspase-3 and phosphatidylserine(PS) were examined by flow cytometry.Results There were no significant differences in Caspase-3 activity and PS erpression between 13C positive children and 13C negative children.Conclusions There is no certain relationship between platelet apoptosis in childhood newly diagnosed ITP and Hp.