摘要目的 探讨膜联蛋白A2 (ANXA2)和微小染色体蛋白7(MCM7)在肝癌组织中的表达及临床意义.方法 采用免疫组化SP法检测ANXA2和MCM7在86例肝细胞肝癌和38例正常肝脏组织中的表达情况,并分析二者与肝癌临床病理学特征的关系.结果 ANXA2在肝细胞肝癌组织中的阳性表达率为83.7％,MCM7在肝细胞肝癌组织中的阳性表达率为77.9％,它们在正常肝脏组织中均未见明显表达(P＜0.01).ANXA2蛋白在肝癌中的表达与乙肝阳性、肿瘤大小及门脉癌栓有关(P＜0.05),MCM7蛋白在肝癌中的表达与甲胎蛋白、肿瘤大小及病理分级有关(P＜0.05).结论 ANXA2和MCM7的表达水平可能是反映肝细胞肝癌发生、发展及生物学行为的重要生物学指标.

abstractsObjective To study the expression of annexinA2 (ANXA2) and minichmmosome maintenance protein 7 (MCM7) in hepatocellular carcinoma tissue and its clinical significance.Methods The expressions of ANXA2 and MCM7 were detected by the immunohistochemistry in 86 cases of hepatocellular carcinoma tissue and 38 normal liver tissue.Their relationships with the clinicopathologic features of HCC were analyzed.Results ANXA2 and MCM7 did not express in normal liver tissue ; the positive rate of ANXA2 in HCC was 83.7％ ; the positive rate of MCM7 in HCC was 77.9％ (P ＜0.01).The expression of ANXA2 protein was related to HbsAg,tumor size and portal tumor thrombosis (P ＜0.05).The expression of MCM7 protein was related to AFP lever,tumor size and the grade of pathological differentiation grade(P ＜ 0.05).Conclusions The expression levels of ANXA2 and/or MCM7 may be important biological marker in the carcinogenesis,progression and biological behaviors of hepatocellular carcinoma.