摘要目的 评价血浆(1,3)-β-D葡聚糖测定(C试验)对慢性阻塞性肺疾病(COPD)合并侵袭性肺部真菌感染(IPrI)的诊断价值.方法 检测98例有IPFI高危因素的COPD患者的G试验值,计算G试验的敏感度及特异度,比较真菌感染组患者与非真菌感染组(1,3)-β-D葡聚糖血浆浓度.结果 以20 pg/ml为临界值,G试验在COPD并IFPI中的敏感度为81％,特异度为86％.真菌感染组患者血浆(1,3)-β-D葡聚糖浓度明显高于非真菌感染组,差异有统计学意义(P＜0.05).结论 G实验用于COPD合并IPFI诊断具有简便、快速、阳性率高的优点,并可作为早期诊断以弥补传统方法的不足.

abstractsObjective To evaluate the diagnosis value of(1,3)-β-D-glucan antigens(G test)on patients with invasive pulmonary fungal infections(IPFI) complicated with chronic obstructive pulmonary disease(COPD).Methods The levels of(1,3)-β-D-glucan antigens in 98 high-risk of IPFI patients with COPD were detected.The sensitivity and specificity of G test was calculated.The(1,3)-β-D-glucan concentrations of fungal infection and non-fungal infection group were compared.Results At a cutoff 20 pg/ml,the sensitivity and specificity of G test for IPFI patients with COPD was 81％ and 86％.The (1,3)-β-D-glucan concentration of patients with fungal infection was significantly higher than that of patients with non-fungal infection (P ＜ 0.05).Conclusions (1,3)-β-D-glucan detection has the advantages of simple,rapid and high positive rate in diagnosis of IPFI patients with COPD.Meanwhile,G test can be used in early diagnosis for making up the deficiency of the traditional method.