摘要目的：对胃肠道间质瘤的临床诊断和治疗效果进行分析。方法对2005年8月至2008年6月的63例胃肠道间质瘤患者的临床资料进行回顾性分析，均采用影像学辅助检查，并对病理切片进行免疫组化分析，观察 CD117和 CD34蛋白的表达。63例患者中12例采用扩大手术治疗，27例采用单纯全切除术，16例采用全切除联合靶向治疗，8例采用扩大手术联合靶向治疗。结果影像学只能发现腹部包块，对疾病无法确诊。术后病理行免疫组化检查 CD117阳性者61例，占96.8%；CD34阳性者41例，占65.1%。未发现两者均为阴性表达的患者。单纯采用扩大切除术与全切除术的患者1、3、5年的生存率比较差异均无统计学意义（P ﹥0.05）。单纯肿瘤扩大切除术和全切除术患者手术后患者的生活质量均比术前有所提高，并且全切除术组比扩大切除术组提高更明显（P ﹤0.05）。全切除术联合靶向治疗患者的1、3、5年生存率均明显高于单纯全切除术患者（P ﹤0.05）。结论免疫组化是确诊胃肠道间质瘤的必要条件，在治疗中，全切除联合靶向治疗更有优势。

abstractsObjective To analyze the diagnosis and treatment of gastrointestinal stromal tumor. Methods From August 2005 to June 2008,63 cases of gastrointestinal stromal tumors were analyzed retrospectively,additional tests were used in imaging,biopsy and immunohistochemical analysis of CD117 and CD34 protein expression was observed. Twelve cases were operated through expanding surgery,27 cases using a simple resection,16 cases with full excision combined with targeted therapy,eight cases of combined targeted therapy using enlargement surgery. Results Imaging can only found ab-dominal mass,the disease can not be diagnosed. Pathological examination CD117 immunohistochemistry positive in 61 ca-ses,accounting for 96. 8% ;CD34 positive in 41 cases,accounting for 65. 1% . Both negative expression of which were not found in patients. The 1,3,5-year survival rate between simply using extended resection and total resection had no signifi-cant difference(P ﹥ 0. 05). Simple tumor enlarged resection and subtotal resection surgery improved the quality of life (P ﹤ 0. 05). Combined targeted therapy in patients with 5-year survival rate was significantly higher than that in patients with total resection(P ﹤ 0. 05). Conclusions Immunohistochemistry is the necessary conditions for diagnose gastrointesti-nal stromal tumors,and targeted therapy combined with subtotal resection has advantages.