摘要目的 探讨标准三联加益生菌疗法与铋剂四联方案对根除幽门螺杆菌的根除率及不良反应的影响.方法 选取101例幽门螺杆菌感染患者并随机分为对照组50例和观察组51例.对照组予以铋剂四联方案治疗,观察组实施阿莫西林+克拉霉素+雷贝拉唑标准三联加益生菌治疗.观察比较两组治疗前后临床症状积分、生活质量评分及Hp根除率、不良反应发生率及复发率.结果 治疗后1周及2周观察组临床症状评分均低于对照组,差异有统计学意义(P ＜0.05);观察组Hp根除率为86.27％,对照组为80.00％,组间比较差异未见统计学意义(P＞0.05);观察组不良反应发生率为7.84％,低于对照组的22.00％,差异有统计学意义(P＜0.05);治疗后随访1年,观察组复发率为5.88％ (3/51),对照组为12.00％ (6/50),组间比较差异未见统计学意义(P＞0.05);治疗后观察组生活质量评分高于对照组,差异有统计学意义(P＜0.05).结论 在标准三联疗法基础上加铋剂或益生菌治疗对幽门螺杆菌的根除率均较高,且复发率低,加用益生菌较加铋剂治疗,不良反应发生率低,可提高患者生活质量.

abstractsObjective To investigate the effect of standard triple therapy combined with probiotic therapy and bismuth quadruple therapy on eradication rates and adverse effects of Helicobacter pylori (Hp).Methods One hundred and one patients with Helicobacter pylori infection were randomly divided into the control group (50 cases) and the observation group (51 cases).The control group was treated by bismuth quadruple therapy,the observation group was treated with amoxicillin,clarithromycin and ray Bella by standard triple therapy combined with probiotics treatment.Before and after treatment,the clinical symptom score,quality of life score and Hp eradication rate,adverse reaction rate and recurrence rate were observed and compared between the two groups.Results The clinical symptom scores of the observation group were lower than those of the control group at 1 week and 2 weeks after treatment,the differences were significant (P ＜ 0.05).The eradication rate of Hp was 86.27％ in the observation group,and 80.00％ in the control group,there was no significant difference between the two groups (P ＞0.05).The incidence of adverse reactions in the observation group was 7.84％,which was lower than that in the control group (22.00％),the difference was significant (P ＜ 0.05).subjects were followed up for 1 year after treatment.The recurrence rate was 5.88％ (3/51) in the observation group and 12.00％ (6/50) in the control group,there was no significant difference between the two groups (P ＞0.05).After treatment,the quality of life of the observation group was higher than that of the control group,and the difference was significant (P ＜ 0.05).Conclusions The eradication rate of Helicobacter pylori is high in the standard triple therapy based on bismuth or probiotics treatment,and the recurrence rate is low,but the adverse reaction rate of the standard triple therapy combined with probiotics therapy is lower,which can improve the quality of life of patients.