摘要目的 回顾性分析多囊卵巢综合征(PCOS)患者D3胚胎冻融移植、囊胚冻融移植和D3胚胎新鲜移植的妊娠结局,探讨PCOS患者全胚冷冻复融周期移植的优势,评价PCOS全胚冷冻复融周期移植胚胎的选择.方法 根据患者移植周期及胚胎发育的天数,将670例因PCOS因素首次行胚胎移植(IVF-ET)患者分为3组:A组314例,为D3胚胎冻融移植组;B组155例,为D3胚胎新鲜移植组;C组201例,为囊胚冻融移植组.结果 A组临床妊娠率、种植率、多胎率和活产率均高于B组(P＞0.05),临床妊娠率、种植率、多胎率显著性低于C组(P＜0.05),活产率低于C组(P＞0.05).B组临床妊娠率、种植率、多胎率和活产率显著性低于C组(P＜0.05).流产率和异位妊娠率:B组＞A组＞C组,但三组差异均未见统计学意义(P＞0.05).三组单胎新生儿体质量和双胎新生儿体质量差异未见统计学意义(P＞0.05).结论 PCOS患者选择D3胚胎冻融移植,可以提高临床妊娠率、种植率和活产率,若选择囊胚冻融移植,则提高临床妊娠率、种植率和活产率,一定程度降低流产率,多胎率也显著性增加.

abstractsObjective To investigate the influencing factors of frozen-thawed embryo transfer and the value of blastocyst transfer after whole embryos cryopreservation in PCOS patients.Methods Six hundred and seventy patients underwent embryo transfer for the first time due to PCOS factors were divided into 3 groups according to embryo transfer cycle and stage of embryo development:group A,314 patients with frozen-thawed D3 embryo transfer;group B,155 patients with fresh D3 embryo transfer;group C,201 patients with frozen-thawed blastocyst transfer.Results The clinical pregnancy rate,implantation rate and multiple pregnancy rate were significant lower in group A than those in group C (P ＜ 0.05).The clinical pregnancy rate,implantation rate,multiple pregnancy rate and live birth rate was significant lower in group A than those in group C (P ＜ 0.05).Conclusions PCOS patients with frozen-thawed D3 embryo transfer is associated with a high clinical pregnancy rate,implantation rate and live birth rate.And frozen-thawed blastocyst transfer is associated with high clinical pregnancy rate,implantation rate,live birth rate and multiple pregnancy rate,and abortion rate is reduced to some extent.