摘要目的 探讨血清相关指标及宫颈长度测量在早产预测中的作用.方法 选择2015年1月至2017年12月生产的孕妇230例,其中早产100例作为观察组,足月产130例作为对照组.比较两组血清C-反应蛋白(CRP)、白细胞介素-6(IL-6)、白细胞计数(WBC)、可溶性细胞黏附分子-1(sICAM-1)及阴道B超下宫颈长度.结果 两组IL-6、CRP、sICAM-1、WBC、宫颈长度差异均有统计学意义(P均<0.05);IL-6≥13 pg/ml预测早产的敏感性为79.00％、特异性为93.75％、阳性预测率为90.80％、阴性预测率为85.11％;sICAM-1≥388 ng/ml预测早产敏感性为69.00％、特异性为93.08％、阳性预测率为88.46％、阴性预测率为79.61％;宫颈长度≤21 mm预测早产敏感性为75.00％、特异性为90.77％、阳性预测率为86.21％、阴性预测率为78.67％.结论 血清IL-6、sICAM-1及宫颈长度是预测早产的良好指标.

abstractsObjective To investigate the role of serum related indicators and the measurement of cervical length in preterm labor prediction. Methods A total of 230 pregnant women were selected,of which 100 women with preterm birth were allocated to observation group and 130 pregnant women who produced in full term were allocated to control group. Serum C-reactive protein (CRP),interleukin-6 (IL-6),white blood cell (WBC)count,soluble cell adhesion molecule-1 (sICAM-1)and vaginal B ul-trasound length in two groups were detected and compared. Results There were significant differences in levels of IL-6,CRP,sICAM-1,WBC and cervical length between the two groups (P < 0. 05). The sensitivity of indicator IL-6 ≥13 pg / ml for predicting premature birth was 79％ and specificity was 93. 75％,prediction value of positive was 90. 80％ and the predictive value of negative was 85. 11％;the sensitivity of indicator sICAM-1≥388 ng / ml in predicting preterm delivery was 69. 00％,specificity was 93. 08％,prediction value of positive was 88. 46％,the predictive value of negative was 79. 61％;the sensitivity of indicator the cervical length ≤21 mm in predicting preterm delivery was 75. 00％,specifici-ty was 90. 77％,prediction value of positive was 86. 21％,the predictive value of negative was 78. 67％ . Conclusions The levels of IL-6,sICAM-1 and measurement of cervical length were sensitive indicators for preterm labor predication.