摘要目的 探讨醒脾养儿颗粒联合去氨加压素治疗单症状性遗尿症的临床效果,以及醒脾养儿颗粒对遗尿症患儿唤醒困难症状的改善情况.方法 选择2016年1月至2018年1月于郑州大学第一附属医院就诊的101例遗尿症患儿(遗尿症组)及正常体检儿童80例(正常组),分析其临床就诊资料及睡眠觉醒评分(AS评分)情况.根据治疗方法将101例遗尿症患儿分为4组:行为治疗组(A组,13例)、单用醒脾养儿颗粒组(B组,16例)、单用去氨加压素组(C组,23例)、联合应用醒脾养儿颗粒及去氨加压素组(D组,49例).比较正常组及遗尿症组患儿的AS评分,比较遗尿症组治疗前后AS评分、疗效及复发情况.结果 遗尿症组患儿AS评分高于正常组;B、C、D组治疗后AS评分低于治疗前,C组治疗前后AS评分差小于B、D组(P<0.05);D组治愈情况(29/49)优于A组(1/13)及B组(1/16),C组治愈情况(12/23)优于A、B组(P<0.05);C组复发率高于D组(66.7％比31.1％,P<0.05).结论 联合应用醒脾养儿颗粒比单用去氨加压素治疗单症状性遗尿症的复发率低,醒脾养儿颗粒能明显改善单症状性遗尿症患儿的唤醒困难程度.

abstractsObjective To discuss the clinical effect of Xingpi Yang'er granule combined with deaminopressin in the treatment of monosymptomatic nocturnal enuresis ( MNE) and arousal difficulty in children. Methods A total of 101 children with nocturnal enuresis ( NE, NE group) and 80 children with normal physical examination ( normal group ) were selected from the First Affiliated Hospital of Zhengzhou University from January 2016 to January 2018 . The clinical data and a difficulty in arousal in sleep score ( AS score) of these children were analyzed. The 101 children with NE were further divided into four groups according to the treatment methods: behavior treatment group ( group A, 13 cases ) , Xingpi Yang'er granule group ( group B, 16 cases) , desmopressin group ( group C, 23 cases) , Xingpi Yang'er granule combined with desmopressin group ( group D, 49 cases) . The AS score, curative effect and recurrence of normal children and NE children before and after treatment were compared. Results The AS score of NE group was higher than that of normal group. After treatment, the AS score of group B, group C and group D declines, and the difference of AS score between preoperative value and postoperative value in group C was greater than that in group B and group D ( P<0. 05 ) . The cure rate of group D (29/49) was higher than that of group A (1/13) and group B (1/16), while that of group C (12/23) was higher than that of group A and group B (P<0. 05). The recurrence rate in group C was higher than that in group D (66. 7％ vs. 31. 1％, P<0. 05). Conclusions Xingpi Yang'er granule&nbsp;combined with desmopressin in the treatment of MNE could bring lower recurrence rate than single desmopressin therapy. Xingpi Yang'er granule can significantly relieve difficulty in awakening children with MNE arousal from sleep.