摘要目的:探讨新活素对急诊经皮冠状动脉介入治疗(PCI)术后急性ST段抬高型心肌梗死(STEMI)患者心功能及心室重构的应用效果。方法:回顾性分析2016年4月至2019年3月在聊城市第三人民医院接受治疗的100例急诊PCI术后STEMI患者的临床资料，依据治疗方法分为对照组与观察组，每组50例。对照组给予常规西药治疗，观察组在常规西药治疗基础上采用新活素治疗。对比两组患者心功能指标[左心室舒张末期内径(LVEDD)、左心室射血分数(LVEF)、心脏指数(CI)、心排出血量(CO)]与心室重构指标[室间隔厚度(LVST)、左室后壁厚度(LVPWT)、左心室心肌质量指数(LVMI)、左室舒张内径(LVDD)]的变化情况。结果:治疗后，两组CO、LVEF、CI值均高于治疗前，LVEDD值低于治疗前，且观察组CO、LVEF、CI值均高于对照组，LVEDD值低于对照组，差异有统计学意义( P<0.05)。治疗后，两组LVST、LVPWT、LVMI、LVDD值均低于治疗前，且观察组低于对照组，差异有统计学意义( P<0.05)。 结论:新活素可有效提升急诊PCI术后STEMI患者的心功能，改善心室重构。

abstractsObjective:To investigate the effects of neovasin on cardiac function and ventricular remodeling in patients with acute ST-segment elevation myocardial infarction (STEMI) after emergency percutaneous coronary intervention (PCI).Methods:The clinical data of 100 patients with STEMI after emergency PCI treated in the Third People’s Hospital of Liaocheng from April 2016 to March 2019 were retrospectively analyzed. According to treatment methods, they were divided into the control group and observation group, with 50 cases in each group. Patients in the control group received conventional western medicine treatment, and patients in the observation group received neovasin treatment on the basis of conventional western medicine treatment. The cardiac function index, such as left ventricular end-diastolic diameter (LVEDD), left ventricular ejection fraction (LVEF), cardiac index (CI), cardiac blood loss (CO), and ventricular remodeling indexes, such as interventricular septum thickness (LVST), left ventricular posterior wall thickness (LVPWT), left ventricular myocardial mass index (LVMI), left ventricular diastolic diameter (LVDD), were compared between the two groups.Results:After treatment, CO, LVEF and CI in the two groups increased, and LVEDD decreased, compared to preoperative levels( P<0.05). In addition, CO, LVEF and CI in the observation group were all higher than those in the control group after treatment, and LVEDD was lower than that in the control group ( P<0.05). Compared to values before treatment, LVST, LVPWT, LVMI and LVDD values of the two groups were lower after treatment ( P<0.05); and LVST, LVPWT, LVMI and LVDD values of the observation group were lower than those of the control group after treatment ( P<0.05). Conclusions:Neovasin can effectively improve cardiac function and ventricular remodeling of STEMI patients after emergency PCI.