摘要目的:探讨替罗非班在急性颅内大血管闭塞机械取栓术后的应用效果。方法:抽取2017年4月至2020年4月临汾市中心医院收治的急性颅内大血管闭塞卒中患者100例，按照随机数字表分为对照组与研究组，每组50例。对照组行机械取栓术治疗，研究组于机械取栓术后继续使用替罗非班治疗。比较两组患者美国国立卫生研究院卒中量表(NIHSS)评分、改良Rankin量表(mRS)评分情况。结果:两组NIHSS评分随术后时间延长而持续降低，术后7 d研究组NIHSS评分低于对照组( P<0.05)。术后30、60、90 d，研究组mRS≤2分者占比高于对照组( P<0.05)。术后，研究组血管再通率(74.00%，37/50)高于对照组(60.00%，30/50)，血管再次闭塞率(4.00%，2/50)低于对照组(14.00%，7/50)，但差异未见统计学意义( P>0.05)。 结论:急性颅内大血管闭塞机械取栓术后继续使用替罗非班治疗可有效提高血管再通率，降低术后颅内大血管再闭塞风险，改善患者神经功能及预后。

abstractsObjective:To investigate the effect of tirofiban after mechanical thrombectomy for acute intracranial large vessel occlusion.Methods:A total of 100 patients with acute intracranial large vessel occlusion stroke admitted to Linfen Central Hospital from April 2017 to April 2020 were selected and divided into the control group and the study group according to a random number table, with 50 cases in each group. The control group received mechanical thrombectomy and the study group continued to use tirofiban after mechanical thrombectomy. The scores of the National Institutes of Health Stroke Scale (NIHSS) and Modified Rankin Scale (mRS) were compared between the two groups.Results:The NIHSS scores of the two groups continued to decrease with the postoperative time, the NIHSS scores of the study group were lower than those of the control group on the 7th day after surgery ( P<0.05). The proportion of patients with mRS≤2 scores in the study group was higher than that in the control group on day 30, 60 and 90 after surgery ( P<0.05). Postoperatively, the recanalization rate of blood vessels of the study group (74.00%, 37/50) was higher than that of the control group (60.00%, 30/50), and the rate of vascular reocclusion (4.00%, 2/50) was lower than that of the control group (14.00%, 7/50), but the differences were not significant ( P>0.05). Conclusions:The continued use of tirofiban therapy after mechanical thrombectomy for acute intracranial large vessel occlusion can effectively increase the vascular recanalization rate, reduce the risk of postoperative intracranial large vessel reocclusion, and improve the neurological function and prognosis of patients.